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AN EXPERIMENTAL STUDY OF THE RADIATION-INDUCED CHANGES ON THE SECRETORY GRANULES OF THE RAT SUBMANDIBULAR GLAND ACINAR CELL

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Abstract

¹æ»ç¼±Á¶»ç¿¡ µû¸¥ Ÿ¾×¼±¼¼Æ÷³» ºÐºñ°ú¸³ÀÇ º¯È­¸¦ °üÂûÇϱâ À§ÇÏ¿© ¹é¼­ÀÇ ¾ÇÇϼ±¿¡
6MV X¼± 5GY¹× 10Gy¸¦ Á¶»çÇÑ ÈÄ ½ÃÀÏ°æ°ú¿¡ µû¶ó °¢°¢ Èñ»ý½ÃÅ°°í ºÐºñ°ú¸³ÀÇ ¹Ì¼¼±¸
Á¶Àû º¯È­¸¦ Åõ°úÀüÀÚÇö¹Ì°æÀ¸·Î °üÂûÇÏ¿© ´ÙÀ½ÀÇ °á°ú¸¦ ¾ò¾ú´Ù.
¾ÇÇϼ±¼¼Æ÷³» ºÐºñ°ú¸³ Àº ¹æ»ç¼±Á¶»çÈÄ 3½Ã°£ ±º¿¡¼­ ¸·°æ°è°¡ ºÒºÐ¸íÇÏ°Ô °üÂûµÇ¾ú°í,
1Àϱº°ú 3Àϱº¿¡¼­´Â ºÐºñ°ú¸³ÀÇ ¼ö¿Í Å©±âÀÇ °¨¼Ò, ÇüÅÂ¿Í ºÐÆ÷ ¹× ³»ºÎ ÀüÀڹеµÀÇ ºÒ±Õ
Àϼº, ¸·ÀÇÆı« µîÀÌ ºÐ¸íÇÏ¿´À¸¸ç, 14Àϱº¿¡¼­ ÇüÅÂ¿Í ºÐÆ÷ÀÇ È¸º¹ÀÌ °üÂûµÇ¾ú°í, 28Àϱº¿¡
¼­ ³»ºÎ ÀüÀڹеµ¿Í ¸·°æ°èÀÇ È¸º¹ÀÌ °üÂûµÇ¾ú´Ù. ¼¼Æ÷³» ¼Ò±â°üµéÀÇ º¯È­´Â °ú¸³¼ºÇüÁú³»
¼¼¸ÁÀÇ ¹è¿­È¥¶õ°ú ´ÜÀý»óÀÌ °üÂûµÇ¾úÀ¸¸ç, °ñÁöü¿¡¼­ÀÇ º¯È­´Â °üÂûµÇÁö ¾Ê¾Ò´Ù. ÀÌ»óÀÇ
¼Ò°ßÀ¸·Î ¹Ì·ç¾îº¸¾Æ ¹æ»ç¼±Á¶»çÈÄ ¾ÇÇϼ±¼¼Æ÷³» ºÐºñ°ú¸³¿¡¼­ ´Ù¾çÇÑ ÇüÅÂÇÐÀû º¯È­°¡ °ü
ÂûµÇ¾ú°í, 5GyÁ¶»ç±º¿¡ ºñÇØ 10GyÁ¶»ç±º¿¡¼­ Ãʱ⠺¯È­°¡ ´õ¿í ºü¸£°í ºÐ¸íÇÏ¿´À¸¸ç, ȸº¹
ÀÌ Áö¿¬µÇ´Â °ÍÀ¸·Î ³ªÅ¸³µ´Ù.
#ÃÊ·Ï#
The purpose of this study was to investigate the irradiation effects on the secretory
granules of the rat submandibular gland acinar cell. For this study, Sprague-Dawley
strain rats were irradiated to their neck region with the dose of 5Gy and 10Gy by 6MV
X-radiation, and sacrificed on the experimental periods after irradiation. The authors
observed the ultrastructural changes of the secretory granules of the rat submandibular
gland acinar cell under a trasmission electron microscope.
The results were as follows:
In the transmission electron microscopic examination, secretory granules were blurred
in limiting membrane on the 3hours groups after irradiation. And they showed decrease
in number, irregularities in shape and distributional pattern, and inhomogeneous internal
electron density on the 1day and 3days groups. After then, these changes were
recovered in shape and distributional pattern on the 14days groups, and changes of
internal electron density and limiting membrane were recovered on the 28days groups
after irradiation. Among the intracellular organelles, rough endoplasmic reticulum was
scattered, but golgi complex was not changed. And such pathologic changes were earlier
and more prominent in 10Gy irradiated groups than in 5Gy irradiated groups.

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